VitaminCBD

Vitamins are defined as substances that you need in order to remain healthy, which are found in food or can be eaten in the form of pills. The skin of our body makes another vitamin, which results when the natural sunlight contacts our skin. Because of the importance of this vitamin and the clothes that we wear, fortified Vitamin D has been infused into milk and other foods to make sure that the body gets enough Vitamin D to make and maintain proper calcium levels for normal bone health.

Over the last 50 years, vitamin D has been credited as the mainstay supplement to maintain healthy bone health and calcium balance. Recent studies have found conflicting evidence as published in the Guardian Oct. 2018.

The new meta-analysis is published in the Lancet Diabetes and Endocrinology journal and led by the longstanding experts on vitamin D Profs Mark Bolland and Andrew Grey from the University of Auckland in New Zealand and Prof Alison Avenell of Aberdeen University.

Bolland said things have changed since 2014, when the last major review of the evidence was carried out. In the last four years, “more than 30 randomized controlled trials on vitamin D and bone health have been published, nearly doubling the evidence base available,” he said.

“Our meta-analysis finds that vitamin D does not prevent fractures, falls or improve bone mineral density, whether at high or low dose.”He said the advice given by doctors and government health departments around the world recommending vitamin D and saying it is helpful in osteoporosis or brittle bone disease, which afflicts older people, should now be altered. “Clinical guidelines should be changed to reflect these findings,” he said.

He said further trials looking at the effects of vitamin D on bone health would be pointless. “On the strength of existing evidence, we believe there is little justification for more trials of vitamin D supplements looking at musculoskeletal outcomes,” he said. [1]

Adding to this growing body of medical science, an alternative approach to maintain optimal bone health was discovered in 1992 called the endocannabinoid system, discovered by Dr. Raphael Mechoulam. This research is particularly exciting because the endocannabinoid system naturally occurs in the body. The endocannabinoid (EC) system. The EC system—named after the marijuana plant Cannabis sativa and its active ingredient delta-9-tetrahydrocannabinol (THC)—is a unique communications system in the brain and body that affects many important functions, including how a person feels, moves, and reacts. The natural chemicals produced by the body that interact within the EC system are called cannabinoids, and like THC, they interact with receptors to regulate these important body functions.

There has been much written about this regulatory system around the world. It has taken a retro-engineering approach of the components of the Cannabis sativa L plant that has taught us that this bodily system is real and works to do what vitamins do—maintain and sustain our health. Over the last several years the international medical community has been conducting preclinical studies. Their findings have shown that.

In general, endocannabinoids seem to suppress or limit the immune system’s inflammatory signals. Professor Prakash Nagarkatti, Vice President for Research at the University of South Carolina whose laboratory studies endocannabinoid regulation of immune responses, told us how tweaking the ECS might be a good way to treat inflammatory diseases.

“Most of our research demonstrates that endocannabinoids are produced upon activation of immune cells and may help regulate the immune response by acting as anti-inflammatory agents. Thus, interventions that manipulate the metabolism or production of endocannabinoids may serve as a novel treatment modality against a wide range of inflammatory disease.” [2]

Further research demonstrates that that cannabinoids may actually promote bone health in certain circumstances.

In 2015, a study published in the Journal of Bone and Mineral Research found that CBD can help with healing fractures. Researchers determined that CBD increased the strength of healed femurs, after they had been broken in some unfortunate laboratory rats.

Also, in Israel in 2015, researchers found that CBD played a role in promoting bone recovery. In a combined study conducted by researchers from Hebrew University of Jerusalem and Tel Aviv University, CBD was found to enhance fracture healing by stimulating production of osteoblasts (bone-building cells). Osteoblast proliferation is critical to forming the “calluses” that bridge the fractures in broken bones. After six to eight weeks, experiments revealed that bone callus size increased in rats that were administered CBD or THC — but not in rats that were given a control substance. The study concluded that “CBD significantly enhanced the mechanical properties and strength of the bone after eight weeks.

”There is clearly a close link between cannabinoids — especially CBD — and bone formation and healing. But with seemingly contradictory findings of studies over the past years, the question certainly warrants closer scrutiny.[3]

As an orthopedic surgeon and medical researcher times 40 plus years, I was taught one thing back in medical school and now many of the medical conclusions taught then are not true today. This is due to the art and science of medicine and the half-life of knowledge of orthopedics or any other medical science. Our ABC’s have not changed, but in orthopedics, the half-life of this scientific knowledge is five years. So, if I do the math, if I have not kept current with current medical studies and research, only 16% of my orthopedic knowledge would be current and relevant. This reality warrants the need for more investment and research on the benefits of endocannabinoid regulation.

Again, vitamins are substances that our bodies need to develop and function normally. They include vitamins A, C, D, E, and K, choline, and the B vitamins (thiamin, riboflavin, niacin, pantothenic acid, biotin, vitamin B6, vitamin B12, and folate/folic acid).

Vitamin CBD has been at work in our biological make-up without a true appreciation until recent research done outside the United States of America has forced a new look at an old friend. The science is complex and not the purpose of this article. The Farm Bill of 2018 which is predicted to be passed by Congress in December 2018 will open the floodgates to a new awareness for this biological system and Vitamin CBD which will be unchained for research and education about all the medical properties found in Cannabis sativa L.

Eric I. Mitchell, MD MA FACPE CPE

Chief Executive Officer

Hemp Commodity Industries, LLC

[1] Guardian Oct. 7 2018

[2] https://www.leafly.com/news/science-tech/what-is-the-endocannabinoid-system

[3] https://cannabisnow.com/cannabis-and-bone-density-studies/

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